Chemotherapeutic Studies in Tuberculosis

Tuberculosis: The Chemotherapeutic Approaches

'[HE' term, chemotherapy of tuberculosis, implies a simplified concept which may have been compromised in the reader's mind by the experience of, successful chemotherapy in other fields. It is not a misplaced pedantry which leads clinicians to speak of the "management" of tuberculosis, but rather a work-a-day acquaintance and understanding of the many diverse pathological conditions involved. T...

Chemotherapeutic Interventions Against Tuberculosis

Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by s...

Chemotherapeutic studies on transplantable mouse tumors.

Transplants of tumors were made in the lower right hind leg, and treatment was begun when the tumor volume was 150-200 mm.3 For lymphosarcoma, this was 12 to 16 days; for mammary carcinoma A ? 179955, 10 to 15 days; for mammary carcinoma 5769, 10 to 15 days; and for solid Erlich ascites tumor, 6 to 8 days after inoculation. Both mammary carcinomas were spontaneous in Strain A mice obtained from...

Chemotherapeutic Studies on Transmitted Mouse Leukemia*

Transmitted mouse leukemia offers a good means of investigating the therapeutic action of chemical and physical agents on leukemic cells. There are few reports on the experimental chemotherapy of leukemia in mammals other than man, except for those on the effect of radioactive substances (8, 9, 11). Therapeutic studies on fowl leukosis are not directly applicable to mammals because leukemia of ...

Studies in Pulmonary Tuberculosis